Synthesis, Cytotoxicity, Biological Assessment and Molecular Docking of a few Dihydropyridines as Xanthine Oxidase Inhibitors
Keywords:Dihydropyridine; Cytotoxic; Xanthine oxidase, Molecular docking
A few of 1,4-dihydropyridine (DHP) derivatives (A-C) were assessed for their cytotoxicity effects against MCF-7 and L929 cells. The candidate compounds were also evaluated as xanthine oxidase (XO) inhibitors. Molecular docking simulation was applied to further examine the binding potential of DHP within XO binding region. Results of the study proved compound B as the cytotoxic agents against both cell lines while no significant XO inhibitory activity could be recorded for B. On the basis of molecular docking studies, different enzyme blocking activities might be attributed to the various binding regions with the enzyme active site.
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Copyright Drug & Advanced Sciences Journal