Synthesis, Cytotoxicity, Biological Assessment and Molecular Docking of a few Dihydropyridines as Xanthine Oxidase Inhibitors

doi: 10.29252/dasj-010102

Authors

  • Hamed Hamze Khosroshahi Biotechnology Research Center, Tabriz University of Medical Sciences, Tabriz, Iran
  • Fariba Namdari Biotechnology Research Center, Tabriz University of Medical Sciences, Tabriz, Iran
  • Mohammad Reza Rashidi Biotechnology Research Center, Tabriz University of Medical Sciences, Tabriz, Iran
  • Siavash Dastmalchi Department of Medicinal Chemistry, Faculty of Pharmacy, Tabriz University of Medical Sciences, Tabriz, Iran
  • Javid Shahbazi Biotechnology Research Center, Tabriz University of Medical Sciences, Tabriz, Iran
  • Behzad Baradaran Immunology Research Center, Tabriz University of Medical Sciences, Tabriz, Iran
  • Ramin Miri Medicinal and Natural Products Chemistry Research Center, Shiraz University of Medical Sciences, Shiraz, Iran
  • Nima Razzaghi-Asl Department of Medicinal Chemistry, School of Pharmacy, Ardabil University of Medical Sciences, Ardabil, Iran
  • Aliasghar Hamidi Department of Medicinal Chemistry, Faculty of Pharmacy, Tabriz University of Medical Sciences, Tabriz, Iran

Keywords:

Dihydropyridine; Cytotoxic; Xanthine oxidase, Molecular docking

Abstract

A few of 1,4-dihydropyridine (DHP) derivatives (A-C) were assessed for their cytotoxicity effects against MCF-7 and L929 cells. The candidate compounds were also evaluated as xanthine oxidase (XO) inhibitors. Molecular docking simulation was applied to further examine the binding potential of DHP within XO binding region. Results of the study proved compound B as the cytotoxic agents against both cell lines while no significant XO inhibitory activity could be recorded for B. On the basis of molecular docking studies, different enzyme blocking activities might be attributed to the various binding regions with the enzyme active site.    

 

Published

2019-07-22

How to Cite

Hamze Khosroshahi, H., Namdari, F., Rashidi, M. R., Dastmalchi, S., Shahbazi, J., Baradaran, B., Miri, R., Razzaghi-Asl, N., & Hamidi, A. (2019). Synthesis, Cytotoxicity, Biological Assessment and Molecular Docking of a few Dihydropyridines as Xanthine Oxidase Inhibitors: doi: 10.29252/dasj-010102. Drug & Advanced Sciences Journal, 1(1), 3-8. Retrieved from https://dasj.pharmacy.arums.ac.ir/index.php/dasj/article/view/9

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